The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

Manel B. Hammouda, Amy E. Ford, Yuan Liu, Jennifer Y. Zhang
2020 Cells  
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in
more » ... r molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
doi:10.3390/cells9040857 pmid:32252279 fatcat:tkka2nbqljdblpnqfii5sgolce