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In this study, we use promoter analysis to show that interaction between Jab1 and p53 induces suppression of p53 activation in U2OS and H1299 cells. Interaction between p53 and Jab1 was further confirmed by immunoprecipitation and immunofluorescent analyses. In particular, Jab1 was able to induce nuclear export of p53 as previously reported. When Jab1 was overexpressed in U2OS cells followed by etoposide or hydrogen peroxide (H2O2), cell death induced by such stresses was protected against. Ondoi:10.5483/bmbrep.2009.42.5.299 pmid:19470245 fatcat:wdwnvoxg4beerlrw7r7knflwym