ASSOCIATION OF LOWER ANTIOXIDANT STATUS WITH ESTIMATED GFR IN HYPERTENSIVES WITH PRESERVED RENAL FUNCTION
English

Roma Rattan, Rasmita Kumari Padhy, Nirupama Devi, Suvendu Sekhar Acharya, Srikrushna Mahapatra
2013 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND AND OBJECTIVES: Renal dysfunction is end organ damage in hypertension. We investigated the association of oxidative stress with estimated glomerular filtration rate in hypertension. METHODS: A total of 116 hypertensive individuals (age 47 ± 10.2 years; 68% males; BMI < 25; without diabetes mellitus, CVD) were included. All the hypertensive subjects were albustix negative. Fasting blood glucose, lipid profile, urea and creatinine was estimated. Serum oxidant load was estimated by
more » ... s estimated by ferrous oxidation products in xylenol orange version 2(FOX2) and antioxidant power of serum was estimated by ferric reducing capacity, FRAP assay. Data is represented as mean± SD. Data was analysed by unpaired two-tailed students t test, Pearson's correlation and linear regression. The estimated GFR was calculated by simplified modification of diet in renal disease study prediction equation and Cockroft-Gault formula. RESULT: Systolic and diastolic blood pressure, lipid profile, serum creatinine and oxidant load was significantly higher in hypertensive subjects (p < 0.001). Total Antioxidant status and estimated GFR was significantly lower in hypertensive subjects. A significant negative correlation was present between oxidative stress and eGFR. INTERPRETATION AND CONCLUSION: Among hypertensive subjects with preserved renal function increased oxidative stress is associated with decreased eGFR. Whether estimation of oxidative stress and adjuvant antioxidant therapy are better prognostic markers requires further research.
doi:10.14260/jemds/306 fatcat:sdrvjl7ll5fwln2xfgwkurkukq