The aim of this study was to determine the effectiveness of intra-articular hyaluronic acid in the patients with knee osteoarthritis. This study being a prospective controlled study included 86 patients with osteoarthritis of knee (Kellegren II & III). The effect of intraarticular hyaluronic acid (hyalgan 500-730kda) on the clinical parameters was noted. A total of 40 males and 46 females fulfilled the inclusion criteria with an age between 55-76 years .Of them 44 received five injections of

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... luronic acid (one injection per week) and 42 received intraarticular saline injection and served as control. A reduction in lequesne score from 13.68±1.25 to 7.85±3.63 was observed (P<0.01).The pain was recorded with the help of visual analog scale of 0-100. The VAS scores were reduced at rest from 43±3 to 16±2 and during weight beaing from 73±1 to 38±2 (P<0.01). This study concluded that hyaluronic acid is effective and well tolerated in the management of chronic primary osteoarthritis.