Astrovirus Pathogenesis [chapter]

Victoria Meliopoulos, Stacey Schultz-Cherry
2012 Astrovirus Research  
Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research,
more » ... ovirus research, including the development of animal models of cell culture systems. Viruses 2017, 9, 22 2 of 10 and nutrients, leading to diarrhea. Additionally, extra-gastrointestinal astrovirus-associated disease has been reported in animals and humans [31] [32] [33] , which could result from the increased intestinal permeability. The definite mechanisms underlying diarrhea and systemic spread remain an area of continual research; increasing our understanding of astrovirus disease will be integral for future treatment and prevention strategies. Recently, studies in both humans and animals have helped to elucidate the molecular and cellular attributes of astrovirus disease. The following review highlights these findings, and outlines necessary and critical steps needed to further astrovirus research.
doi:10.1007/978-1-4614-4735-1_4 fatcat:yjb3o3so6bh2zjayv63ckfl4ya