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G-Protein-Coupled Receptor Kinase Activity in Hypertension : Increased Vascular and Lymphocyte G-Protein Receptor Kinase-2 Protein Expression
Impaired receptor-stimulated adenylyl cyclase activation has been observed in lymphocytes from hypertensive subjects and has been linked to an increase in lymphocyte G-protein receptor kinase-2 (GRK-2) protein expression. However, whether the increase in lymphocyte GRK-2 reflected an increase in vascular GRK-2 was unknown. Therefore, we compared GRK-2 protein expression in lymphocytes and aortas obtained from normotensive Wistar rats, Wistar-Kyoto rats (WKY), and spontaneously hypertensive ratsdoi:10.1161/01.hyp.35.1.38 pmid:10642272 fatcat:idxzgjkrg5gtpoz6bngoyt3zky