Blunting of the hypoxemia-induced decrease in GFR by the intrarenal infusion of ANP. P.H. Wiesel, B.A. Semmekrot, f-P. Guignard, Service de Pédiatrie, CHUV -1011, Lausanne, Switzerland. Hypoxemia, as seen in severe respiratory distress, can profoundly affect renal function. In animal models, acute hypoxemia induces renal vasoconstriction, with a concomitant decrease in diuresis, glomerular filtration rate (GFR) and renal blood flow (RBF). The effect of atrial natriuretic peptide (ANP), a

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... with potent diuretic, natriuretic and vasodilating properties, was investigated in adult rabbits undergoing acute hypoxemia. Renal functions of the right control kidney and left salineinfused kidney were separately assessed in 7 anesthetized and mechan-