Although many researches focusing on the prognosis of MM, they do not distinguish whether the patients are accompanied by bEMD. Our study found that the clinical features, overall survival (OS) and progression free survival (PFS) of patients with and without bEMD had no statistical significance. Diffused bEMD predicted worse prognosis compared with focal bEMD. PET/CT is sensitive in discovering bEMD than whole body low dose CT suggesting PET-CT to be a promising technique for initial staging.

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... gh β2-MG and low ALB indicated shorter survival in patients with bEMD. Our cohort of patients is limited, and it is a retrospective study. It was the limitation that we couldn't be sure whether our conclusion was applicable in other or larger cohorts.