Immune modulatory effects of probiotic streptococcuc thermophilus on human monocytes [article]

Narges Dargahi, Joshua Johnson, Vasso Apostolopoulos
2020 bioRxiv   pre-print
Ingesting probiotics contributes to the development of a healthy microflora in the gastrointestinal tract with established benefits to human health. Some of these beneficial effects may be through modulating of the immune system and probiotics have become more common in the treatment of many inflammatory and immune disorders. We demonstrate a range of immune modulating effects of streptococcuc thermophilus by human monocytes, including, decreased mRNA expression of IL-1R, IL-18, IFNgR1, IFNaR1,
more » ... 18, IFNgR1, IFNaR1, CCL2, CCR5, TLR-1, TLR-2, TLR-4, TLR-5, TLR-6, TLR-8, CD14, CD86, CD4, ITGAM, LYZ, TYK2, IFNR1, IRAK-1, NOD2, MYD88, ITGAM, SLC11A1, and, increased expression of IL-1a, IL-1b, IL-2, IL-6, IL-8, IL-23, IFNg, TNFa, CSF-2. Routine administration of streptococcuc thermophilus in fermented dairy products, and their consumption may be beneficial to the treatment/management of inflammatory and autoimmune diseases. Keywords: Probiotics; microbiome; Lactic acid bacteria; streptococcuc thermophilus; Peripheral blood mononuclear cells; Monocyte; RNA; Innate immune response; Adaptive immune response; Inflammation
doi:10.1101/2020.08.27.271346 fatcat:kzjdgr5ofvdsbe4ii3xnw57m5i