Tiotropium in asthma: From bench to bedside

Lyndon Mansfield, Jonathan A. Bernstein
2019 Respiratory Medicine  
Tiotropium is a long-acting muscarinic antagonist approved for maintenance treatment of asthma in children, adolescents, and adults in the United States, and recommended as add-on treatment for uncontrolled asthma despite treatment with inhaled corticosteroids and/or long-acting beta-2 agonists. This review traces the journey of tiotropium from its historical origins through early preclinical testing to human clinical trials and real-life studies.
doi:10.1016/j.rmed.2019.06.008 pmid:31212121 fatcat:g2zn6hfjh5bxnofrpkewqccuc4