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Self-Templated Nucleation in Peptide and Protein Aggregation
2008
Physical Review Letters
Peptides and proteins exhibit a common tendency to assemble into highly ordered fibrillar aggregates, whose formation proceeds in a nucleation-dependent manner that is often preceded by the formation of disordered oligomeric assemblies. This process has received much attention because disordered oligomeric aggregates have been associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Here we describe a self-templated nucleation mechanism that determines the
doi:10.1103/physrevlett.101.258101
pmid:19113754
fatcat:igg6fw3pl5exbk45z6ccprosp4