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Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify their functions. Here, we analyze the expression and function of alternative exons in the C. elegans RyRdoi:10.1371/journal.pgen.1009102 pmid:33104696 fatcat:jxofviebazex5krv7v5423rkwq