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A structural model of the active ribosome-bound membrane protein insertase YidC
2014
eLife
The integration of most membrane proteins into the cytoplasmic membrane of bacteria occurs co-translationally. The universally conserved YidC protein mediates this process either individually as a membrane protein insertase, or in concert with the SecY complex. Here, we present a structural model of YidC based on evolutionary co-variation analysis, lipid-versus-protein-exposure and molecular dynamics simulations. The model suggests a distinctive arrangement of the conserved five transmembrane
doi:10.7554/elife.03035
pmid:25012291
pmcid:PMC4124156
fatcat:2park6rpcngangzt6pcx7s2mpa