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Integrin ␣ 4 ␤ 7 mediates rolling adhesion in Ca 2+ and Ca 2+ + Mg 2+ , and firm adhesion in Mg 2+ and Mn 2+ , mimicking the two key steps in leukocyte accumulation in inflamed vasculature. We mutated an interlinked linear array of three divalent cation-binding sites present in integrin ␤-subunit I-like domains. The middle, metal ion-dependent adhesion site (MIDAS) is required for both rolling and firm adhesion. One polar site, that adjacent to MIDAS (ADMIDAS), is required for rolling becausedoi:10.1038/nsb1011 pmid:14608374 fatcat:okzh4a4rsffuzmseyhp4ip6xzq