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The lymph node at a glance – how spatial organization optimizes the immune response
2020
Journal of Cell Science
A hallmark of the mammalian immune system is its ability to respond efficiently to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore, a robust immune response requires the coordination of a diverse range of cells present at low frequencies within the host. This problem is solved, in part, by concentrating antigens, antigen-presenting cells and antigen-responsive cells in lymph nodes (LNs). Beyond housing these cell types in one location, LNs are highly
doi:10.1242/jcs.241828
pmid:32144196
fatcat:p2nhs5np6vez3cj7pq4ljlo4le