Disrupted fronto-temporal function in panic disorder: a resting-state connectome study [post]

Yun Wu, Yuan Zhong, Gang Zheng, Ya Liu, Manlong Pang, Huazhen Xu, Huachen Ding, Chun Wang, Ning Zhang
2021 unpublished
Recent neuroimaging studies have identified altered activations and connectivity among many brain regions as potential biomarkers for panic disorder. However, little was known about how topological properties would change in panic disorder. Therefore, a graph-theoretical approach was applied in this study to construct functional networks of patients and healthy controls to discover topological changes in panic disorder. 31 patients and 33 matched healthy controls underwent resting-state
more » ... al magnetic resonance imaging. Brain network of each participant was structured using the Anatomical Automatic Labeling template as nodes and connectivity matrixes as edges. Then, topological organizations of networks were calculated. Network-based statistic analysis was conducted and global and nodal properties were compared between patients and controls. Patients with panic disorder showed small-world attribute, which was lower than that in controls. Patients revealed decreased nodal efficiency in superior and middle frontal gyrus, right superior temporal gyrus and left middle temporal gyrus. Decreased functional connectivity was found in panic disorder between right middle temporal gyrus and extensive temporal regions. Results indicated decreased function of global and regional information transmission in panic disorder, highlighted the disrupted "top-down" processing in fronto-temporal regions and emphasized the role of temporal regions in the pathology of panic disorder.
doi:10.21203/rs.3.rs-240681/v1 fatcat:cnunt4oql5butewjea27ecblxy