Severe Covid-19 infection in type 1 and type 2 diabetes mellitus during the first three waves in Sweden [post]

Jon Edqvist, Christina Lundberg, Karin Andreasson, Lena Björck, Pigi Dikaiou, Johnny Ludvigsson, Marcus Lind, Martin Adiels, Annika Rosengren
2023 unpublished
<p> </p> <p><strong>Objective </strong>Type 2 diabetes is an established risk factor for hospitalization and death in COVID-19 infection while findings with respect to type 1 diabetes have been diverging. </p> <p><strong>Research Design and Methods </strong>Using nationwide health registries, we identified all patients aged ≥18 years with type 1 and type 2 diabetes in Sweden. Odds ratios (ORs) describe general- and age specific risk of being hospitalized, in need of intensive care, or dying,
more » ... usted for age, socioeconomic factors and coexisting conditions, compared to individuals without diabetes. Machine learning models were used to find predictors of outcomes among COVID-19-positive individuals with diabetes. </p> <p><strong>Results </strong>Until June 30, 2021, we identified 365 (0.71%) and 11,684 (2.31%) hospitalizations in 51,402 and 504,337 patients with type 1 and 2 diabetes, respectively, with 67 (0.13%) and 2,848 (0.56%) cases requiring ICU care, while there were 68 (0.13%) and 4,020 (0.80%) deaths, which we compared with 7,824,181 individuals without diabetes (41,810 hospitalizations (0.53%), 8,753 (0.11%) needing ICU care, and 10,160 (0.13%) deaths). Although those with type 1 diabetes had moderately raised odds of being hospitalized, multiple-adjusted OR 1.38(95% CI 1.24-1.53), there was no independent effect on ICU care or death (ORs of 1.21(95% CI 0.94-1.52) and 1.13(95% CI 0.88-1.48)). Age and socioeconomic factors were the dominating features for predicting hospitalization and death in both types of diabetes. </p> <p><strong>Conclusions Type 2 diabetes were associated with increased odds for all of the outcomes, whereas </strong>patients with type 1 diabetes had moderately increased odds of hospitalization but not ICU care and death. </p>
doi:10.2337/figshare.21685727 fatcat:2imy2zgxfzgyfpmgm4nhqgrrqm