Some Central Nervous System Activities of Nerium Oleander Linn (Kaner) Flower Extract

KG Singhal, GD Gupta
2011 Tropical Journal of Pharmaceutical Research  
Purpose: The purpose of the study was to evaluate the activity of 50 % hydroalcohol flower extract of Nerium oleander Linn. on the central nervous system (CNS) of mice. Methods: The effect of the 50 % hydroalcohol extract of N. oleander flowers at dosage levels of 100 and 200 mg/kg p.o. on the locomotor activity of mice was measured with an actophotometer while muscle relaxant activity was evaluated on rotarod apparatus. Also, the anticonvulsant activity of the extract in mice (following
more » ... e (following maximal electroshock and pentyleneterazol-induced convulsion) as well as the potentiation of pentobarbital-induced sleep were determined using standard procedures. Diazepam was used as the reference standard. Result: The extract (at doses of 100 and 200 mg/kg) significantly reduced (p < 0.01) spontaneous locomotor activity and also potentiated pentobarbital-induced sleep. At the higher dose (200 mg/kg) the extract showed 66 % protection against electroshock-induced convulsions while the lower dose (100 mg/kg) produced a significant reduction (p < 0.01) in pentylenetetrazol (PTZ)-induced convulsions. Conclusion: The ethanol extract of Nerium oleander flowers has anticonvulsant activity in an experimental animal model.
doi:10.4314/tjpr.v10i4.11 fatcat:uf3expxacnba3b5ycaq3ozyqce