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Purpose: The purpose of the study was to evaluate the activity of 50 % hydroalcohol flower extract of Nerium oleander Linn. on the central nervous system (CNS) of mice. Methods: The effect of the 50 % hydroalcohol extract of N. oleander flowers at dosage levels of 100 and 200 mg/kg p.o. on the locomotor activity of mice was measured with an actophotometer while muscle relaxant activity was evaluated on rotarod apparatus. Also, the anticonvulsant activity of the extract in mice (followingdoi:10.4314/tjpr.v10i4.11 fatcat:uf3expxacnba3b5ycaq3ozyqce