Neuroanatomical basis of paroxysmal sympathetic hyperactivity: A diffusion tensor imaging analysis

Holly E. Hinson, Louis Puybasset, Nicolas Weiss, Vincent Perlbarg, Habib Benali, Damien Galanaud, Mike Lasarev, Robert D. Stevens
2015 Brain Injury  
Primary objective-Paroxysmal sympathetic hyperactivity (PSH) is observed in a sub-set of patients with moderate-to-severe traumatic brain injury (TBI). The neuroanatomical basis of PSH is poorly understood. It is hypothesized that PSH is linked to changes in connectivity within the central autonomic network. Research design-Retrospective analysis in a sub-set of patients from a multi-centre, prospective cohort study Methods and procedures-Adult patients who were <3 weeks after severe TBI were
more » ... rolled and screened for PSH using a standard definition. Patients underwent multimodal MRI, which included quantitative diffusion tensor imaging. Main outcomes and results-Principal component analysis (PCA) was used to resolve the set of tracts into components. Ability to predict PSH was evaluated via area under the receiver operating characteristic (AUROC) and tree-based classification analyses. Among 102 enrolled patients, 16 met criteria for PSH. The first principle component was significantly associated (p =
doi:10.3109/02699052.2014.995229 pmid:25565392 pmcid:PMC4397147 fatcat:47rxubkwdfee7c4zbyzf3372pe