STUDY OF PREVALENCE AND PATTERN OF ANAEMIA IN HYPOTHYROIDISM
English

Periasamy S, Prabhu G, Balamurugan S, Aleemsarwar Aleemsarwar
2016 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND Hypothyroidism can cause a wide variety of haematological disorders and anaemia could be its first manifestation. Numerous mechanisms are involved in the pathogenesis of this anaemia that can be microcytic, macrocytic and normocytic. Microcytic anaemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anaemia is caused by malabsorption of vitamin B12, folic acid, pernicious anaemia and inadequate nutrition. Normocytic anaemia is characterised by
more » ... reticulopenia, hypoplasia of erythroid lineage, decreased level of erythropoietin; mainly regular erythrocyte survival. We designed this study to investigate the incidence of anaemia and its morphological pattern in hypothyroidism patients in rural population. AIM AND OBJECTIVE This study is designed to investigate the incidence of anaemia and its morphological pattern in hypothyroidism patients in rural population. METHODS AND MATERIALS A prospective observational study was done in patients treated with evidence of hypothyroidism in RMMCH from February 2016 to May 2016. Patients with age >18 years, both genders on treatment with hypothyroidism and newly diagnosed were included. Patients with secondary cause for anaemia, malignancy, CKD and evidence of blood loss were excluded. A detailed clinical history and blood count with smear study was done after obtaining informed consent. RESULT In our present study, female predominance was 82% with more common age group between 31-40 years at 36%. Incidence of anaemia was found to be 70% where microcytic hypochromic anaemia was present in 34 patients (68 %) followed by macrocytic anaemia in 14 patients (28%) and normocytic normochromic anaemia in 2 patients (4%). CONCLUSION Incidence of anaemia was found to be 70% in hypothyroidism. Microcytic hypochromic anaemia was commonest type of anaemia in hypothyroid patients in rural population.
doi:10.14260/jemds/2016/1275 fatcat:krc5cbbugrhstdrqkqkiurahty