Genomic Mapping and Mapping Databases [chapter]

Peter S. White, Tara C. Matise
2002 Methods of biochemical analysis  
A few years ago, only a handful of ready-made maps of the human genome existed, and these were low-resolution maps of small areas. Biomedical researchers wishing to localize and clone a disease gene were forced, by and large, to map their region of interest, a time-consuming and painstaking process. This situation has changed dramatically in recent years, and there are now high-quality genome-wide maps of several different types containing tens of thousands of DNA markers. With the pending
more » ... ability of a finished human sequence, most efforts to construct genomic maps will come to a halt; however, integrated maps, genome catalogues, and comprehensive databases linking positional and functional genomic data will become even more valuable. Genome projects in other organisms are at various stages, ranging from having only a handful of available maps to having a complete sequence. By taking advantage of the available maps and DNA sequence, a researcher can, in many cases, focus in on a candidate region by searching public mapping databases in a matter of hours rather than by performing laboratory experiments over a course of months.
doi:10.1002/0471223921.ch6 fatcat:x4v2e6gl7vc7dn5esov7sanque