Preparation of bisoprolol fumarate nasal spray and its nasal delivery in rats

Gu Fugen, Hao Duo, Meng Gendalai, Wu Chunzhi, Wang Yi
2015 Pakistan Journal of Pharmaceutical Sciences  
The aim of the present work was to prepare a nasal spray of bisoprolol fumarate (BF). The Pharmacokinetics and relative bioavailability of the BF nasal formulation were evaluated in Wistar rats. The BF nasal spray after administration exhibited very fast absorption and higher plasma drug concentration. The maximum plasma concentration (C(max)) and the time to reach it (T(max)) were 409.5 ng/ml and 3.6 min for the BF nasal spray, 39.4 ng/ml and 26.7 min for the drug solution, respectively. The
more » ... oavailability of the BF nasal spray was greater than 1500.0%. Meantime, the effect of the BF nasal spray on nasal mucociliary movement was also studied with a toad palate model. The BF nasal preparation showed minor ciliotoxicity, but the adverse effect was temporary and reversible.
pmid:26639509 fatcat:nrr7mcgzdrdd3pt3j6p4a7enxy