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Preparation of bisoprolol fumarate nasal spray and its nasal delivery in rats
2015
Pakistan Journal of Pharmaceutical Sciences
The aim of the present work was to prepare a nasal spray of bisoprolol fumarate (BF). The Pharmacokinetics and relative bioavailability of the BF nasal formulation were evaluated in Wistar rats. The BF nasal spray after administration exhibited very fast absorption and higher plasma drug concentration. The maximum plasma concentration (C(max)) and the time to reach it (T(max)) were 409.5 ng/ml and 3.6 min for the BF nasal spray, 39.4 ng/ml and 26.7 min for the drug solution, respectively. The
pmid:26639509
fatcat:nrr7mcgzdrdd3pt3j6p4a7enxy