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Proceedings of 3rd International Electronic Conference on Medicinal Chemistry
Quinolines of natural origin have shown antileishmanial activities on several experimental leishmaniasis models. However, a classical daily treament with 2-npropylquinoline (2-n-PQ) on five consecutive days in mice model is not sufficient to cure the mice infected with Leishmania donovani as the activity requires a 10-day treatment duration whatever the route (oral, parenteral) because of a short half-life elimination of the drug. Therefore, 2-n-PQ derivatives were bound to solubledoi:10.3390/ecmc-3-04649 fatcat:n4pfi55vrjgs5kbgd6fcrrtacq