Assessment of the tropicamide concentration on pupillary response test for Alzheimer's disease

A. Iijima, M. Haida, N. Ishikawa, H. Minamitani, Y. Shinohara
2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
Pupillary response test using a cholinergic antagonist, tropicamide was focused as a diagnostic method of Alzheimer's disease (AD). Ever since the test was reported, there have been studies that non-AD individuals showed same responses to tropicamide compared to AD individuals and that the test could not be useful for the diagnosis of AD. In this study, we changed the experimental conditions especially the tropicamide concentration, and proposed the new test under this condition. We made
more » ... mide half the concentration of the original test and performed the pupil test for non-AD subjects. We obtained the results that non-AD patients could not be hypersensitive to the new concentration of the eye drops. This could be helpful for the test to reduce the false positive rates. 4 Abstract Subject Terms Report Classification unclassified Classification of this page unclassified Classification of Abstract unclassified Limitation of Abstract UU Number of Pages
doi:10.1109/iembs.2001.1019108 fatcat:c6wqlh4e7jfupjsskuppwh67pa