Effect of acetoacetate on urinary excretion of xanthurenic acid and other tryptophan metabolites in rats

M. C. Nath, N. V. Shastri
1969 British Journal of Nutrition  
I . An experiment was performed to study the eEect of sodium acetoacetate on urinary excretion of santhurenic acid and other tryptophan metabolites in male albino rats. z. Animals were fed on a nicotinic acid-deficient diet for a period of 3 weeks. The animals were then divided into two groups and, after the basal urinary excretion of the tryptophan metabolites had been estimated, the rats of both the groups were force-fed with L-tryptophan (100 mg per rat), the rats of the second group being
more » ... multaneously injected intraperitoncally with acetoacetate (zoo mg/kg body-weight), and the urine samples during the following 24 h were collected and analysed. 3. Acetoacetate-treated rats given tryptophan were found to excrete significantly greater amounts of kynurenine, hydroxykynurenine and xanthurenic acid than the corresponding control rats. There was no ditference between the amounts of kynurenic acid excreted by the animals in the two groups. https://www.cambridge.org/core/terms. https://doi.
doi:10.1079/bjn19690018 pmid:5766785 fatcat:ssf7qsb6zjbc5fvokgh5wfdnfm