Internet Archive Scholar

PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF MODAFINIL USING PEG6000 AS HYDROPHILIC CARRIER FOR IMPROVEMENT OF DISSOLUTION PROFILE

Paras Kathiriya
2014 Journal of Drug Delivery and Therapeutics  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (490.7 kB)
https://web.archive.org/web/20200213060746/http://jddtonline.info/index.php/jddt/article/download/845/505

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL. The file type is application/pdf.

Solid dispersions of modafinil were prepared using polyethyleneglycols, in various proportions by melting, solvent evaporation and kneading method. Based on the solubility, PEG6000 was selected and solid dispersion batch F6 containing drug:PEG6000 in 1:3 ration was formulated as tablet (batch TF6) and evaluated for in-vitro drug dissolution and six month stability; and the results were compared with that of tablet containing physical mixture of drug:PEG6000 in 1:3 ratio (batch TF24) and
more » ... on tablet (batch CT) containing pure drug. Tablet batch TF24 had shown significant improvement of dissolution profile of modafinil when compared with that of tablet batch TF6 and CT. Present study conclusively demonstrated that PEG6000 enhanced water solubility of modafinil by amorphisation, which was confirmed XRD and DSC; and also the melting method was found better than solvent evaporation.
doi:10.22270/jddt.v4i3.845 fatcat:fslljwabpfgsfdtccjs5zub7de
Open Access
Citation

Paras Kathiriya. "PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF MODAFINIL USING PEG6000 AS HYDROPHILIC CARRIER FOR IMPROVEMENT OF DISSOLUTION PROFILE." Journal of Drug Delivery and Therapeutics 4.3 (2014)