Analysis of Relationships Between Prethrombotic States and Cervical Cancer

You-Hong Sun, Lin Cui, Jue Chen, Min Wang, Jian-Jun Liu, Xing-Xiang Liu, Xin-En Huang
2015 Asian Pacific Journal of Cancer Prevention  
Objective: To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, as well as survival time for patients with cervical cancer. Methods: Patients with first diagnosis of cervical cancer were subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results, patients are divided into an observation group (abnormal) and control group (normal). Results: For 106 patients with cervical cancer, 38 with abnormal D-dimer, the
more » ... rate is 35.9%, of which stage Ⅰ accounted for 6.5%, stageⅡ 38.5%, stage Ⅲ 50%, and stage Ⅳ 61.1% (p=0.013); The level of D-dimers in stageⅠ wass 0.87±0.68ug/ ml, while in stage Ⅱ it was 1.50±1.35ug/ml, stage Ⅲ 2.60±1.86ug/ml and stage Ⅳ 18.6±53.4ug/ml (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p <0.01). In the observation group, survival time was 15.1±5.8 months, while for control group it was 21.0±5.4 months, the difference between two groups being highly significant (p=0.000). Conclusion: There is a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer.
doi:10.7314/apjcp.2015.16.14.6163 fatcat:fecf67adobgzfojq2q5ivhxsw4