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Cofilin takes the lead
2004
Journal of Cell Science
Cofilin has emerged as a key regulator of actin dynamics at the leading edge of motile cells. Through its actinsevering activity, it creates new actin barbed ends for polymerization and also depolymerizes old actin filaments. Its function is tightly regulated in the cell. Spatially, its activity is restricted by other actin-binding proteins, such as tropomyosin, which compete for accessibility of actin filament populations in different regions of the cell. At the molecular level, it is
doi:10.1242/jcs.01631
pmid:15615780
fatcat:g2xq4ibhwvgyjjlxqkzbroly6a