Cytotoxic sesquiterpene lactones fromEupatorium lindleyanum

N.-Y. Yang, S.-H. Qian, J.-A. Duan, P. Li, L.-J. Tian
2007 Journal of Asian natural products research  
Three new germacrane sesquiterpenes, eupalinolides C-E (1-3), along with three known germacrane sesquiterpenes, eupalinolide A (4), eupalinolide B (5), and 3b-acetoxy-8b-(4 0 -hydroxytigloyloxy)-14hydroxycostunolide (6), were isolated from Eupatorium lindleyanum. They were tested for cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. The results showed that these compounds demonstrated potent cytotoxicity. The structures of the compounds were elucidated by means of 1 H
more » ... ted by means of 1 H and 13 C NMR spectroscopic analysis, including 2D NMR experiments.
doi:10.1080/10286020600727673 pmid:17613619 fatcat:hc4nsausebeybf7fpc3rxy5udq