The Prevalence of Digestive Tract Defects in China: A Population-Based Study [post]

Fangfang Song, Jie Chen, Wei Cai
2020 unpublished
Objectives: The prevalence of congenital digestive tract defects among Chinese people is rarely reported. The aim of this study was to investigate the incidence of digestive tract defects in mainland China and reported the clinical outcomes of these cases. Methods: This research describes a local population-based study of registered births in Jiaxing, China from January 2015 to December 2019. Prevalence estimates (per 10,000 births) of digestive tract malformations were calculated. We used the
more » ... 2 test to compare the differences between categorical variables. Results: In this study a total of 76 cases of digestive tract malformations were included. We calculated the following incidence rates per 10,000 births: 1.65 for esophageal atresia; 1.24 for congenital defects of gastric musculature; 2.33 for hypertrophic pyloric stenosis; 3.72 for duodenal and intestinal atresia; 2.25 for congenital malrotation of intestine; 1.45 for Hirschsprung's disease; 4.75 for anal atresia/stricture; and 1.40 for biliary atresia. There were 31 cases (40.8%) of low birth weight (<2500g), 28 cases (36.8%) were premature births (<37 weeks), and 25 cases (32.9%) had concomitant congenital heart disease. Conclusions: This study estimated the incidence of digestive tract malformations, and the findings may provide a foundation for future epidemiologic studies of these congenital diseases in mainland China. In addition, we found that roughly one third of our subjects with digestive tract defects also had concomitant congenital heart disease, suggesting a link between the two which may warrant further investigation. Moreover, our data will also be helpful in determining the resources needed for basic and public health research into digestive tract malformation in China.
doi:10.21203/rs.3.rs-132228/v1 fatcat:yffxjbsosffjld2pmqovq3yr7i