Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al3+, Cu2+, Hg2+and Pb2+: Experimental and Theoretical Study

Rahmatollah Rahimi, Maryam Khosravi, Mohammd H. H. Tehrani, Mahboubeh Rabbani, Ebrahim Safavi
2016 Journal of the Brazilian Chemical Society  
Solid-phase peptide synthesis of dipeptide (histidine-β-alanine) as a chelating agent examined by common N-9-fluorenylmethyloxycarbonyl-N-trityl-L-histidine and tert-butyloxycarbonyl-βalanine-OH amino acid derivatives. Trityl chloride resin was used as a carrier resin. The molecular structure of the dipeptide was definite by using different methods such as ultraviolet visible (UV-Vis), Fourier transform infrared (FTIR), proton ( 1 H) nuclear magnetic ressonance (NMR) and liquid
more » ... id chromatography-mass spectrometry (LC-MS) and the chelating property of synthesized dipeptide was investigated for removing of metal ions Al 3+ , Cu 2+ , Hg 2+ and Pb 2+ in vitro. In addition, the pharmacological and biological activities of dipeptide were examined by prediction of activity spectra for substances (PASS) program.
doi:10.5935/0103-5053.20160064 fatcat:uekmevihxbfqfi4vq77bmqasne