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Quantitative Prediction of the Pharmacological Effects and Averse Reactions Based on Pharmacokinetics and Pharmacodynamics
Drug Metabolism and Pharmacokinetics
For the quantitative estimation of the therapeutic/pharmacological effects and adverse/toxic reactions of drugs act on a specific receptor, we developed an integrated pharmacokinetic system incorporat ing pharmacokinetics, receptor occupancy theory and a ternary complex model. The developed system ena bled to predict the optimal dosage for an investigational drug by using pre-clinical and clinical data (phase I study) under development, and to assess quantitatively the intensity of itsdoi:10.2133/dmpk.15.386 fatcat:l4wy3pjw4jca7jljacr6l7j2rq