Bulges in left-handed G-quadruplexes

Poulomi Das, Khac Huy Ngo, Fernaldo Richtia Winnerdy, Arijit Maity, Blaž Bakalar, Yves Mechulam, Emmanuelle Schmitt, Anh Tuân Phan
2021 Nucleic Acids Research  
G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges.
more » ... Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
doi:10.1093/nar/gkaa1259 pmid:33503265 fatcat:7vu4ggqkrjfwvjsvj5feoj5mmu