Nanotechnology is the study of developing peculiar particles (1-100 nanometres (nm)) of matter at an atomic, molecular, and supramolecular scale. These nanoparticles possess unique properties such as large surface area, fewer side effects, bioavailability, decrease the toxicity, and prolonged drug release. Some inorganic metals nanoparticles like Ti, Se, Zn, Ag, Ce, Au, and Fe play possess antonymous bioactivities. Selenium is the essential trace element and essential micronutrient in the

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... ical system. There are 25 selenoproteins in the human body possessing oxidoreductase activity; therefore, regulating the physiological redox balance in the organs system. Selenium nanoparticles (SeNPs) have exclusive properties and bioactivities as compared to traditional selenium supplements. Therefore, SeNPs have been attracted worldwide interest as a therapeutic agent and food additive. In this review, we have discussed the therapeutics applications of selenium nanoparticles.