Detecting Molecular Fingerprints in Single Molecule Force Spectroscopy Using Pattern Recognition

Hendrik Dietz, Matthias Rief
2007 Japanese Journal of Applied Physics  
Single molecule force spectroscopy has given experimental access to the mechanical properties of protein molecules. Typically, less than 1% of the experimental recordings reflect true single molecule events due to abundant surface and multiple-molecule interactions. A key issue in single molecule force spectroscopy is thus to identify the characteristic mechanical "fingerprint" of a specific protein in noisy data sets. Here, we present an objective pattern recognition algorithm that is able to identify fingerprints in such noisy data sets.
doi:10.1143/jjap.46.5540 fatcat:u7sq2tvkcjbzjiktcwuop5bux4