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Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
2020
Science Advances
Synaptic transmission is the predominant form of communication in the brain. It requires functionally specialized molecular machineries constituted by thousands of interacting synaptic proteins. Here, we made use of recent advances in cross-linking mass spectrometry (XL-MS) in combination with biochemical and computational approaches to reveal the architecture and assembly of synaptic protein complexes from mouse brain hippocampus and cerebellum. We obtained 11,999 unique lysine-lysine
doi:10.1126/sciadv.aax5783
pmid:32128395
pmcid:PMC7030922
fatcat:ydm7bdudine7de5zdkcereezy4