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The emergence of high-throughput technologies for measuring biological systems has introduced problems for data interpretation that must be addressed for proper inference. First, analysis techniques need to be matched to the biological system, reflecting in their mathematical structure the underlying behavior being studied. When this is not done, mathematical techniques will generate answers, but the values and reliability estimates may not accurately reflect the biology. Second, analysisdoi:10.1093/bib/bbp044 pmid:19854753 pmcid:PMC3700349 fatcat:takbpogtrnfmfbc6v2cazhfffy