Elevated FSH concentrations in imminent ovarian failure are associated with higher FSH and LH pulse amplitude and response to GnRH

Corry H. de Koning, Corrie Popp-Snijders, Joop Schoemaker, Cornelis B. Lambalk
2000 Human Reproduction  
at the time of recruitment of follicles, is elevated due to diminished ovarian feedback of steroids and inhibins (Sherman Joop Schoemaker and Cornelis B.Lambalk and Korenman 1975; Lee et al., 1988; MacNaughton et al., Research Institute for Endocrinology, Reproduction and 1992). Inhibins are dimeric proteins that selectively inhibit Metabolism, Division of Reproductive Endocrinology and FSH secretion. Inhibin A is composed of a common α subunit Infertility, and a βA subunit, and inhibin B
more » ... ts of an α subunit Amsterdam, The Netherlands combined with a βB subunit. In recent years, studies on the differential secretion of inhibin A and inhibin B in the 1 To whom correspondence should be addressed at: Reproductive Endocrinology and Infertility, Department of Obstetrics and menstrual cycle (Groome et al., 1996) and in-situ hybridization Gynaecology, Vrije Universiteit Medical Centre, PO Box 7057, studies (Roberts et al., 1993) have shown that inhibin A 1007 MB Amsterdam, The Netherlands. appears to be primarily secreted by the mature follicle and
doi:10.1093/humrep/15.7.1452 pmid:10875849 fatcat:a33q7sopujb7rnc6jgt5vorf2m