Validation of analytical methods for determination of methamphetamine using Fourier Transform Infrared (FTIR) Spectroscopy has been done. Parameter validation method are the repeatability of the system (precision), accuracy, linear ranges, limit of detection (LOD) and limit of quantification (LOQ). Samples was prepared by mixing a weighed portion of methamphetamine standard and alum and swirled flatly to homogeneous mixture. The mixture with total weighed of powder obtained is approximately 1.0

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... g. This sample was analysis using FTIR. The results of the study showed that the correlation of determination analysis methamphetamine using FTIR was R 2 =0.9998 at functional group with wave length number 698.83 cm -1 . Precision, RSD Horwitz, LOQ, LOD and recovery of the validation of analytical methods for determination of methamphetamine using FTIR were found to be 0.0087%, 2.052%, 2.3035%, 7.6786%, and 104.2%, respectively. This method have uncertainty of measurement is 0.8552%. The final result and uncertainty was (84.3334 ± 0.8552) % of methamphetamine in sample. As a conclusion, the validation of analytical methods for determination of methamphetamine using FTIR is very good method. This method is simplicity of sample preparation and low cost reagents.