Introduction. Ultraviolet radiation is necessary for a person to function normally, but prolonged exposure to sunlight, including ultraviolet radiation of spectrum C, leads to cancer of the skin. Purpose: the development of phytocosmeceutical agents on a natural basis, reducing the period of adaptation of the human body to ultraviolet radiation, and the search for primary test cultures for testing the developed protective agents. Materials and methods. In the work, the natural mechanism for

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... oring the vital activity of microorganisms under the short-term exposure to ultraviolet radiation of spectrum C is studied. The possibility of reducing the period of adaptation of the human body to ultraviolet radiation of spectrum C through the use of a protective phytocosmeceutical agent developed by the author is studied. The possibility of using yeast cells as a primary test culture for testing new phytocosmeceutical protective agents has been tested for the first time. Results. The study identified the requirements for protective equipment of the human body against ultraviolet radiation of spectrum C for use in extreme conditions where there are significant violations of the ozone layer. To protect against excessive insolation, a phytocosmeceutical based on ingredients of plant origin was developed, aimed at inducing melanogenesis. The results show that it is acceptable to use Saccharomyces cerevisiae Meyen ex E.C. Hansen as the primary test culture for testing UV-C protective agents. Findings. A natural phytocosmeceutical protective product has been developed that reduces the period of adaptation of the human body to ultraviolet radiation due to the induction of melanogenesis. A convenient object was found that can be used as a primary test culture when testing protective agents against ultraviolet radiation of spectrum C.