Interleukin-25 induces allergic inflammation

Hideaki Kouzaki, Takeshi Shimizu
2012 Journal of Japan Society of Immunology & Allergology in Otolaryngology  
Immune cells were recognized to play a central role in pathophysiological concepts such as asthma. Recently, it is worth noting that role of airway epithelial cell for pathogenesis or exacerbation of allergic diseases. Epithelial cells make up not only the fi rst line of defense against inhaled environmental factors, such as pathogens, allergens, and pollutants, but not act function in the regulation of immune responses through the production of cytokines and chemokines and via interaction with
more » ... ia interaction with cells of immune systems. There are increasing evidences that epithelial cells are recognized as a main source of Th2 type infl ammation. It is suggest that exposed of inhaled allergen against epithelial cells may result in part from decreased epithelial barrier and innate immune responses including TSLP, IL-25, IL-33, subsequent the development and/or exacerbation of allergic diseases. IL-25 (also known as IL-17E) is a member of the IL-17 family of cytokines. IL-25 acts in promoting a Th2-type immune response and affects in recently identifi ed type 2 innate lymphoid cells. This review summarizes the current knowledge regarding role of IL-25 and the mechanism of IL-25 production outside airway epithelial cells.
doi:10.5648/jjiao.30.237 fatcat:47x63cfnsrgd5pcx4vttfjkr34