Aim: To Evaluate the efficacy of TLE regimen in prevention of mother to child transmission of HIV.Method: All women who tested positive for HIV and delivered between August 2013 to May 2015 were included in the study and was started on TLE regimen(Tenofovir 300mg,Lamuvidine 300mg, Efavirenz 600mg)at the earliest AN visit,and continued thereafter lifelong.The baby was started on syrup Nevirapine 2mg/Kg for 6 weeks of life and 12 weeks if the mother was started on ART later than 12 weeks of

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... ion.The infants were tested for HIV with PCR at 6 weeks,6 months,12months and 18 months.Results:Of the 91 live births,6 infants died in the neonatal period. Of the 74 babies followed up 5 tested positive for HIV and 69 were negative. The transmission rate of HIV was 6.7% and the efficacy of TLE regimen was 93.2%.Conclusion:The risk of transmission of HIV from mother to child had declined with the use of combination ART and the emergence of drug resistance was reduced.