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Evaluating, Comparing, and Interpreting Protein Domain Hierarchies
2014
Journal of Computational Biology
Arranging protein domain sequences hierarchically into evolutionarily divergent subgroups is important for investigating evolutionary history, for speeding up web-based similarity searches, for identifying sequence determinants of protein function, and for genome annotation. However, whether or not a particular hierarchy is optimal is often unclear, and independently constructed hierarchies for the same domain can often differ significantly. This article describes methods for statistically
doi:10.1089/cmb.2013.0098
pmid:24559108
pmcid:PMC3962652
fatcat:ozlal4en5zbavbohr6556kc46m