PO-0406 The Contribution Of Prothrombotic Disorders To Perinatal Arterial Ischaemic Stroke (pais): A Study Of Case-control Parent-child Pairs

J Arnaez, A Martin-Ancel, V Tenorio, G Arca-Diaz, A Garcia-Alix
2014 Archives of Disease in Childhood  
extraction (FTOE) 24 h after birth in infants have reported to be associated with adverse outcomes. Near-infraredtime-resolved spectroscopy (TRS) device enables the simultaneous assessment of quantitative hemodynamics, and absolute values of (rSO 2 ) and cerebral bloodvolume (CBV). The purpose of our study was to determine the usefulness of both rSO 2 and CBV measured by TRS in infants with asphyxia after birth. Methods Twenty-six infants with asphyxia (Apgar score < 7 at 1 min after birth)
more » ... divided into 2 groups: those with hypoxicischaemic encephalopathy (HIE; HIE group, n = 5) and those without hypoxic-ischaemic encephalopathy (non-HIE group, n = 21). rSO 2 and FTOE were measured by TRS at 12, 24, 48, and 72 h after birth. Results rSO 2 was significantly higher and FTOE was significantly lower in the HIE group (n = 5) than in the non-HIE group (n = 21) at 12, 24, 48, and 72 h after birth. CBV was significantly higher in the HIE group (n = 5) than in the non-HIE (n = 21) from 3-6 h after birth through all measurement time points. Conclusions Changes in CBV occurred earlier than those in rSO 2 . Thus, CBV may be an early predictive parameterfor adverse outcomes in infants with asphyxia after birth. Abstract PO-0405 Table 1 Baseline characteristics of enrolled infants Poster abstracts A378 Arch Dis Child 2014;99(Suppl 2):A1-A620
doi:10.1136/archdischild-2014-307384.1052 fatcat:ic2czq6o3rg2nn52qk74by7jpa