Prolactin in the Immune System [chapter]

Lorenza Daz, Mauricio Daz, Leticia Gonzlez, Sal Lira-Albarrn, Fernando Larrea, Isabel Mndez
2013 Prolactin  
PRL was originally identified as a neuroendocrine hormone of pituitary origin; however, its synthesis is not limited to the hypophysis since numerous extrapituitary tissues also express this protein, including the placenta, ovary, testis, mammary gland, skin, adipose tissue, endothelial cells, and immune cells [1] . This wide-spread PRL expression might explain its involvement in very different processes such as reproduction, metabolism, immunology, and behavior. PRL expression and secretion
more » ... regulated by different stimuli provided by the environment and the internal milieu. Although pituitary PRL secretion is under a tonic and cAMP and modulators of the cAMP/CREB pathway Consistent evidence, including studies in different leukemic cell lines as well as PBMC from normal patients, has shown that PRL gene expression is significantly stimulated by cAMP,
doi:10.5772/53538 fatcat:b3hkfj76efd5hbjhsdv2pqsucy