A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis

Tohru MICHITSUJI, Yoshiro HORAI, Ayaka SAKO, Taro ASANO, Nozomi IWANAGA, Yasumori IZUMI, Atsushi KAWAKAMI
2017 Japanese Journal of Clinical Immunology  
A female in her sixties with slowly progressive type 1 diabetes mellitus (SPT1DM) and chronic thyroiditis was referred to our rheumatology department with swelling in her fingers. A prominent atherosclerotic lesion was revealed upon brain magnetic resonance imaging, and she was found to have mixed connective tissue disease (MCTD) positive for proteinase 3 (PR3)antineutrophil cytoplasmic antibody (ANCA). This rare case of MCTD accompanying SPT1DM and PR3-ANCA suggested that a synergy between
more » ... synergy between MCTD and PR3-ANCA triggers atherosclerosis.
doi:10.2177/jsci.40.467 pmid:29367532 fatcat:qtmgfdbk3vgd3bl3ywlpd47z2e