It is our pleasure to welcome you to the 40 th anniversary edition of the International Conference on Computer-Aided Design! Since the global COVID-19 pandemic is still prevailing worldwide, the ICCAD 2021 Executive Committee decided to proceed with a virtualized solution for the conference in the second year from 1-4 November. A virtual conference leads to new challenges due to the missing personal interaction. However, the organizers are leeen to provide an interesting program involving

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... ent technical contributions while also focusing on the networleing aspects. In the end, we aim at creating a unique conference experience. For facilitating this plan, and thanles to the rapidly deployed vaccines and strict hygienic measures, ICCAD will be extended to offer a unique opportunity for an In-Person Networleing Event in Munich, Germany, on 5 November. This one-day event will focus on networleing to mitigate the effects of the missing personal exchange. Jointly sponsored by ACM and IEEE, ICCAD is the premier forum to explore emerging technology challenges in electronic design automation, present leading-edge R&D solutions, and identify emerging technologies for design automation research areas. The members of the executive committee, the technical program committee, and numerous volunteers have spent an enormous effort to prepare an outstanding technical program. We are glad to announce that we again had a significant increase in the number of regular paper submissions with 514 papers going through the complete review peer-review process. This strong submission record amidst a global pandemic emphasizes the high relevance and the recognition of the conference within, but not limited to, the CAD community. For handling such an enormous submission number, we have carefully created 15 tracles and invited outstanding technical program committee members from both industry and academia worldwide for each tracle.