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AFM Manipulation Of Small Fibrin Networks
2009
Biophysical Journal
increasing load. Little, however, is known about the mechanics of E-selectin bonds with its ligands. We tested the load-dependence of bond rupture for Eselectin, and its dependence on the history of load application, by using the distribution of load between multiple receptor-ligand bonds to create a complex loading history. Briefly, an E-selectin-coated bead was held in a laser trap and touched to the vertical surface of a bead coated with sialyl lewis A (sLe a ), allowing one or more bonds to
doi:10.1016/j.bpj.2008.12.092
fatcat:6xndpg5zjrdgdodbajo7q5z4ou