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inactivation process in WT channels. To investigate the structural changes that underlie the unusual behaviour of this mutant, we performed a series of MD simulations of the pore domain of WT hKv1.5 and T480A. Analysis of the trajectories shows that T480A affects the stability and flexibility of the filter region and the surrounding pore loop. These results show that residue T480 (located outside the pore region that determines the integrity of the selectivity filter) affects the stability ofdoi:10.1016/j.bpj.2008.12.3474 fatcat:w2zlabvmwfdozngpsyjw4l42qu