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Biogenesis of a Solid Condensate: Amyloid Bodies
[post]
2019
unpublished
This year marks the 20th anniversary of the discovery that proteins with various cellular functions can be temporarily immobilized in the nucleolus, a process known as nucleolar sequestration. This review reflects on the progress made to understand the physiological roles of nucleolar sequestration and the mechanisms involved in protein immobilization. We discuss how nucleolar sequestration consists of a highly choreographed amyloidogenic liquid-to-solid phase transition that converts the
doi:10.20944/preprints201903.0108.v1
fatcat:xz4xmg4n6zaz5myla72paxluti